修改配置后是否重启了 nginx？php-fpm 错误日志有没有内容？

在设置里面的配置文件 -- vhosts.conf 去设置伪静态吧，从来没在面板上成功过。

轻装上阵 php artisan serve

看 nginx 的错误日志

location / {
    try_files $uri $uri/ /index.php?$query_string;
 }

然后重启服务试试。

看看文档部署《Laravel 9 中文文档》

server {
    listen 80;
    listen [::]:80;
    server_name example.com;
    root /srv/example.com/public;

    add_header X-Frame-Options "SAMEORIGIN";
    add_header X-Content-Type-Options "nosniff";

    index index.php;

    charset utf-8;

    location / {
        try_files $uri $uri/ /index.php?$query_string;
    }

    location = /favicon.ico { access_log off; log_not_found off; }
    location = /robots.txt  { access_log off; log_not_found off; }

    error_page 404 /index.php;

    location ~ \.php$ {
        fastcgi_pass unix:/var/run/php/php8.0-fpm.sock;
        fastcgi_param SCRIPT_FILENAME $realpath_root$fastcgi_script_name;
        include fastcgi_params;
    }

    location ~ /\.(?!well-known).* {
        deny all;
    }
}

composer install

.env配置 和 vendor 都正常吗

多看文档吧

php artisan key:generate